Anti-RNF212 Antibody Picoband® 0,00647 Vervoeging

This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

RNF212

285498

Q495C1

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human RNF212 recombinant protein (Position: Q12-E271) .

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Flow Cytometry

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Immunogen affinity purified.

Liquid

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

1. Ahuja, J. S., Sandhu, R., Mainpal, R., Lawson, C., Henley, H., Hunt, P. A., Yanowitz, J. L., Borner, G. V. Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome. Science 355: 408-411, 2017. 2. Jantsch, V., Pasierbek, P., Mueller, M. M., Schweizer, D., Jantsch, M., Loidl, J. Targeted gene knockout reveals a role in meiotic recombination for ZHP-3, a Zip3-related protein in Caenorhabditis elegans. Molec. Cell. Biol. 24: 7998-8006, 2004. 3. Kong, A., Thorleifsson, G., Stefansson, H., Masson, G., Helgason, A., Gudbjartsson, D. F., Jonsdottir, G. M., Gudjonsson, S. A., Sverrisson, S., Thorlacius, T., Jonasdottir, A., Hardarson, G. A., Palsson, S. T., Frigge, M. L., Gulcher, J. R., Thorsteinsdottir, U., Stefansson, K. Sequence variants in the RNF212 gene associate with genome-wide recombination rate. Science 319: 1398-1401, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Eva-1 homolog A, regulator of programmed cell death

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.