Anti-ROBO4 Antibody Picoband® 0,00647 Vervoeging

Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene. Predicted to enable cell-cell adhesion mediator activity. Involved in angiogenesis and establishment of endothelial barrier. Located in extracellular exosome. Implicated in aortic valve disease 3.

Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a; ITGAL; CD11A

ROBO4

54538

Q8WZ75

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human ROBO4 recombinant protein (Position: D108-A933) .

Leukocytes.

Flow Cytometry

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells

Immunogen affinity purified.

Liquid

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

1. Bedell, V. M., Yeo, S.-Y., Park, K. W., Chung, J., Seth, P., Shivalingappa, V., Zhao, J., Obara, T., Sukhatme, V. P., Drummond, I. A., Li, D. Y., Ramchandran, R. roundabout4 is essential for angiogenesis in vivo. Proc. Nat. Acad. Sci. 102: 6373-6378, 2005. 2. Gould, R. A., Aziz, H., Woods, C. E., Seman-Senderos, M. A., Sparks, E., Preuss, C., Wunnemann, F., Bedja, D., Moats, C. R., McClymont, S. A., Rose, R., Sobreira, N., and 33 others. ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm. Nature Genet. 51: 42-50, 2019. 3. Huminiecki, L., Gorn, M., Suchting, S., Poulsom, R., Bicknell, R. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics 79: 547-552, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

128770 MW

6

Integrin alpha-L

Membrane; Single-pass type I membrane protein.

Integrin alpha-L

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.