Anti-ROCK1 Antibody Picoband® 0,00647 Vervoeging

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

Ornithine carbamoyltransferase, mitochondrial;2.1.3.3; Ornithine transcarbamylase; OTCase; OTC

ROCK1

6093

Q13464

Human, Monkey, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human ROCK1 recombinant protein (Position: K601-R833) .

Mainly expressed in liver and intestinal mucosa.

Flow Cytometry

Biochemicals, Chemical Type, Neuroscience, Neurotransmission, Obesity, Receptors / Channels

Immunogen affinity purified.

Liquid

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

1. Anderson, S. C., SundarRaj, N. Regulation of a Rho-associated kinase expression during the corneal epithelial cell cycle. Invest. Ophthal. Vis. Sci. 42: 933-940, 2001. 2. Bito, H., Furuyashiki, T., Ishihara, H., Shibasaki, Y., Ohashi, K., Mizuno, K., Maekawa, M., Ishizaki, T., Narumiya, S. A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron 26: 431-441, 2000. 3. Bivalacqua, T. J., Champion, H. C., Usta, M. F., Cellek, S., Chitaley, K., Webb, R. C., Lewis, R. L., Mills, T. M., Hellstrom, W. J. G., Kadowitz, P. J. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc. Nat. Acad. Sci. 101: 9121-9126, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39935 MW

6

Ornithine carbamoyltransferase, mitochondrial

Mitochondrion matrix.

Ornithine carbamoyltransferase, mitochondrial

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.