Anti-RPGRIP1L Antibody Picoband® fluoro647 Vervoeging

The protein encoded by this gene can localize to the basal body-centrosome complex or to primary cilia and centrosomes in ciliated cells. The encoded protein has been found to interact with nephrocystin-4. Defects in this gene are a cause of Joubert syndrome type 7 (JBTS7) and Meckel syndrome type 5 (MKS5) .

Endothelial cell-specific molecule 1; ESM-1; ESM1

RPGRIP1L

23322

Q68CZ1

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human RPGRIP1L recombinant protein (Position: E608-D1264) .

Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

Flow Cytometry

Cell Type Markers, Tags & Cell Markers

Immunogen affinity purified.

Liquid

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.

1. Arts, H. H., Doherty, D., van Beersum, S. E. C., Parisi, M. A., Letteboer, S. J. F., Gorden, N. T., Peters, T. A., Marker, T., Voesenek, K., Kartono, A., Ozyurek, H., Farin, F. M., Kroes, H. Y., Wolfrum, U., Brunner, H. G., Cremers, F. P. M., Glass, I. A., Knoers, N. V. A. M., Roepman, R. Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome. Nature Genet. 39: 882-888, 2007. 2. Brancati, F., Travaglini, L., Zablocka, D., Boltshauser, E., Accorsi, P., Montagna, G., Silhavy, J. L., Barrano, G., Bertini, E., Emma, F., Rigoli, L., the International JSRD Study Group, Dallapiccola, B., Gleeson, J. G., Valente, E. M. RPGRIP1L mutations are mainly associated with the cerebello-renal phenotype of Joubert syndrome-related disorders. Clin. Genet. 74: 164-170, 2008. 3. Delous, M., Baala, L., Salomon, R., Laclef, C., Vierkotten, J., Tory, K., Golzio, C., Lacoste, T., Besse, L., Ozilou, C., Moutkine, I., Hellman, N. E., and 25 others. The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nature Genet. 39: 875-881, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Endothelial cell specific molecule 1

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.