Anti-RPS4/X/Y1/Y2 Antibody Picoband® fluoro550 Vervoeging

40S ribosomal protein S4, X isoform is a protein that in humans is encoded by the RPS4X gene. Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y) . The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Tudor domain-containing protein 3; TDRD3

RPS4/X/Y1/Y2

6191/6192/140032

P62701/RPS4Y1/Q8TD47

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human RPS4/X/Y1/Y2 recombinant protein (Position: M1-G263) .

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Flow Cytometry

Adaptive Immunity, B Cells, Immunoglobulins, Immunology

Immunogen affinity purified.

Liquid

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

1. Fisher, E. M. C., Beer-Romero, P., Brown, L. G., Ridley, A., McNeil, J. A., Lawrence, J. B., Willard, H. F., Bieber, F. R., Page, D. C. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. Cell 63: 1205-1218, 1990. 2. Geerkens, C., Just, W., Held, K. R., Vogel, W. Ullrich-Turner syndrome is not caused by haploinsufficiency of RPS4X. Hum. Genet. 97: 39-44, 1996. 3. Hamvas, R. M., Brown, S. D., Keer, J. T., Fisher, E. M., Romero, P., Zinn, A., Page, D. The mapping of the locus Rps4 to the X-inactivation region in the mouse. (Abstract) Cytogenet. Cell Genet. 58: 2065-2066, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Tudor domain containing 3

Nucleus. Cytoplasm.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.