Anti-RREB1 Antibody Picoband® 0,00647 Vervoeging

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene. The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene.

Fructose-bisphosphate aldolase B; Liver-type aldolase; ALDOB; ALDB

RREB1

6239

Q92766

Human

No cross-reactivity with other proteins.

E.coli-derived human RREB1 recombinant protein (Position: K732-Q1559) .

Pancreas-specific (at protein level) . Loss of expression is seen in ductal type pancreas cancers.

Flow Cytometry

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Immunogen affinity purified.

Liquid

Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. ly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in ing the differentiation of retinal progenitors towards horizontal and amacrine fates.

1. Carson, E. B., McMahon, M., Baylin, S. B., Nelkin, B. D. Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation. Cancer Res. 55: 2048-2052, 1995. 2. Flajollet, S., Poras, I., Carosella, E. D., Moreau, P. RREB-1 is a transcriptional repressor of HLA-G. J. Immun. 183: 6948-6959, 2009. 3. Kent, O. A., Saha, M., Coyaud, E., Burston, H. E., Law, N., Dadson, K., Chen, S., Laurent, E. M., St-Germain, J., Sun, R. X., Matsumoto, Y., Cowen, J., and 10 others. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes. Nature Commun. 11: 4673, 2020.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Aldolase, fructose-bisphosphate B

Nucleus. Cytoplasm.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.