Anti-RRM1 Antibody Picoband® 31.0647 Vervoeging

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene. This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.

Semaphorin-3A; Semaphorin III; Sema III; SEMA3A; SEMAD

RRM1

6240

P23921

Human

No cross-reactivity with other proteins.

E.coli-derived human RRM1 recombinant protein (Position: D129-Q730) .

Flow Cytometry

Axonal Guidance Proteins, Cardiogenesis, Cardiovascular, Growth and Development, Hypertrophy, Neurology Process, Neuroscience, Transcription Factors/Regulators

Immunogen affinity purified.

Liquid

Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.

1. Brissenden, J. E., Caras, I., Thelander, L., Francke, U. The structural gene for the M1 subunit of human ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse. Exp. Cell Res. 174: 302-308, 1988. 2. Byrne, J. A., Smith, P. J. The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma. Hum. Genet. 91: 275-277, 1993. 3. Byrne, J., Smith, P. Human polymorphic probe pE1.8 detects SacI polymorphism in the ribonucleotide reductase M1 subunit gene. Hum. Genet. 87: 376 only, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Semaphorin 3A

Secreted .

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.