Anti-RRS1 Antibody Picoband® 0,00647 Vervoeging

Ribosome biogenesis regulatory protein homolog is a protein that in humans is encoded by the RRS1 gene. RRS1 involved in ribosomal large subunit assembly and may regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.

Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; TNFSF18; AITRL, GITRL, TL6; UNQ149/PRO175

RRS1

23212

Q15050

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the C-terminus of human RRS1, which shares 95.5% and 100% amino acid (aa) sequence identity with mouse and rat RRS1, respectively.

Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Flow Cytometry

Cancer, Cardiovascular, Cell Type Markers, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Tags & Cell Markers, TNF Superfamily, Vasculature

Immunogen affinity purified.

Liquid

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569) . Promotes leukocyte adhesion to endothelial cells (PubMed:23892569) . Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity) .

1. Gambe, A. E., Matsunaga, S., Takata, H., Ono-Maniwa, R., Baba, A., Uchiyama, S., Fukui, K. A nucleolar protein RRS1 contributes to chromosome congression. FEBS Lett. 583: 1951-1956, 2009. 2. Gross, M. B. Personal Communication. Baltimore, Md. 1/31/2019. 3. Tsuno, A., Miyoshi, K., Tsujii, R., Miyakawa, T., Mizuta, K. RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. Molec. Cell. Biol. 20: 2066-2074, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

TNF superfamily member 18

Cell membrane

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.