Anti-RS1 Antibody Picoband® 0,00647 Vervoeging

Retinoschisin also known as X-linked juvenile retinoschisis protein is a lectin that in humans is encoded by the RS1 gene. This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision.

RS1

6247

O15537

Human, Mouse

E.coli-derived human RS1 recombinant protein (Position: Y34-A224) . Human RS1 shares 96.9% amino acid (aa) sequence identity with mouse RS1.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Byrne, J., Warburton, D. Male excess among anatomically normal fetuses in spontaneous abortions. Am. J. Med. Genet. 26: 605-611, 1987. 2. Eriksson, A. W., Vainio-Mattila, B., Krause, U., Fellman, J., Forsius, H. Secondary sex ratio in families with X-chromosomal disorders. Hereditas 57: 373-381, 1967. 3. Gehrig, A., Weber, B. H. F., Lorenz, B., Andrassi, M. First molecular evidence for a de novo mutation in RS1 (XLRS1) associated with X-linked juvenile retinoschisis. J. Med. Genet. 36: 932-934, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

25 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.