Anti-RSBN1 Antibody Picoband® fluoro488 Vervoeging

Predicted to enable dioxygenase activity and metal ion binding activity. Predicted to be involved in chromatin organization. Predicted to be active in nucleus.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

RSBN1

54665

Q5VWQ0

Human

No cross-reactivity with other proteins.

E.coli-derived human RSBN1 recombinant protein (Position: M1-S798) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 6/23/2014. 2. Takahashi, T., Tanaka, H., Iguchi, N., Kitamura, K., Chen, Y., Maekawa, M., Nishimura, H., Ohta, H., Miyagawa, Y., Matsumiya, K., Okuyama, A., Nishimune, Y. Rosbin: a novel homeobox-like protein gene expressed exclusively in round spermatids. Biol. Reprod. 70: 1485-1492, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.