Anti-RTF1 Antibody Picoband® 0,00647 Vervoeging

Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) is a protein that in humans is encoded by the RTF1 gene. This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA.

Protein phosphatase 1 regulatory subunit 14A;17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17; PPP1R14A; CPI17, PPP1INL

RTF1

23168

Q92541

Human, Monkey

No cross-reactivity with other proteins

E.coli-derived human RTF1 recombinant protein (Position: S77-K705) .

Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. .

Flow Cytometry

Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Immunogen affinity purified.

Liquid

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

1. Nagase, T., Seki, N., Ishikawa, K., Ohira, M., Kawarabayasi, Y., Ohara, O., Tanaka, A., Kotani, H., Miyajima, N., Nomura, N. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 3: 321-329, 1996. 2. Warner, M. H., Roinick, K. L., Arndt, K. M. Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by ing cotranscriptional histone modification. Molec. Cell. Biol. 27: 6103-6115, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

16693 MW

6

Protein phosphatase 1 regulatory subunit 14A

Cytoplasm .

Protein phosphatase 1 regulatory subunit 14A

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.