Anti-RTN4IP1 Antibody Picoband® fluoro488 Vervoeging

This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants.

Follicular dendritic cell secreted peptide; FDC secreted protein; FDC-SP; FDCSP; C4orf7; UNQ733/PRO1419

RTN4IP1

84816

Q8WWV3

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human RTN4IP1 recombinant protein (Position: M1-K381) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Immunology, Secreted Molecules

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Angebault, C., Guichet, P.-O., Talmat-Amar, Y., Charif, M., Gerber, S., Fares-Taie, L., Gueguen, N., Halloy, F., Moore, D., Amati-Bonneau, P., Manes, G., Hebrard, M., and 21 others. Recessive mutations in RTN4IP1 cause isolated and syndromic optic neuropathies. Am. J. Hum. Genet. 97: 754-760, 2015. Note: Erratum: Am. J. Hum. Genet. 97: 769 only, 2015. 2. Charif, M., Nasca, A., Thompson, K., Gerber, S., Makowski, C., Mazaheri, N., Bris, C., Goudenege, D., Legati, A., Maroofian, R., Shariati, G., Lamantea, E., and 30 others. Neurologic phenotypes associated with mutations in RTN4IP1 (OPA10) in children and young adults. JAMA Neurol. 75: 105-113, 2018. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 10/28/2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

9700 MW

6

Follicular dendritic cell secreted peptide

Secreted.

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.