Anti-RUNX1/RUNX2/RUNX3 Konijn Monoklonale Antilichaam

Boster Bio Anti-RUNX1/RUNX2/RUNX3 Rabbit Monoclonal Antibody catalog # M00086. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha B; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; RUNX1; AML1, CBFA2

RUNX1

861

Q01196/Q13761/Q13950

Human, Mouse, Rat

A synthesized peptide derived from human RUNX1/RUNX2/RUNX3

Clone: DOG-18

Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.

WB, IHC, ICC, IF, IP, Flow Cytometry

Neuroscience, Oncoproteins, Oncoproteins/Suppressors, Organogenesis, Skeletal Development, Stem Cells, Transcription, Transcription Factors

Affinity-chromatography

0.5mg/ml

Liquid

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down- regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532) . .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00086

48737 MW

75 kDa

Runt-related transcription factor 1

Nucleus.

P2X purinoceptor 1

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.