Anti-SA2/STAG2 Antibody Picoband®

Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Boster Bio Anti-SA2/STAG2 Antibody Picoband® catalog # A03624-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Protocadherin-15; PCDH15; USH1F

STAG2

10735

Q8N3U4

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SA2/STAG2 recombinant protein (Position: E750-M1175) .

Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney. CD1 isoforms, such as isoform 1, have a limited pattern of expression and is detected in testis, retina and cochlea. CD2 isoforms, such as isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen, testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely expressed.

WB, IHC, ICC, IF, Flow Cytometry, ELISA

Cancer Susceptibility, Epigenetics and Nuclear Signaling, Transcription, Tumor Suppressors

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.

1. Aoi, H., Lei, M., Mizuguchi, T., Nishioka, N., Goto, T., Miyama, S., Suzuki, T., Iwama, K., Uchiyama, Y., Mitsuhashi, S., Itakura, A., Takeda, S., Matsumoto, N. Nonsense variants in STAG2 result in distinct sex-dependent phenotypes. J. Hum. Genet. 64: 487-492, 2019. Note: Retraction: J. Hum. Genet. 65: 811 only, 2020. 2. Balbas-Martinez, C., Sagrera, A., Carrillo-de-Santa-Pau, E., Earl, J., Marquez, M., Vazquez, M., Lapi, E., Castro-Giner, F., Beltran, S., Bayes, M., Carrato, A., Cigudosa, J. C., and 21 others. Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nature Genet. 45: 1464-1469, 2013. 3. Carramolino, L., Lee, B. C., Zaballos. A., Peled, A., Barthelemy, I., Shav-Tal, Y., Prieto, I., Carmi, P., Gothelf, Y., Gonzalez de Buitrago, G., Aracil, M., Marquez, G., Barbero, J. L., Zipori, D. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. Gene 195: 151-159, 1997. Note: Erratum: Gene 206: 283 only, 1998.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A03624-1

28461 MW

141 kDa

6

Protocadherin related 15

Cell membrane. Single-pass type I. membrane protein. Secreted.

Breast cancer metastasis-suppressor 1

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.