Anti-SA2/STAG2 Antibody Picoband® fluoro488 Vervoeging

Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Protocadherin-15; PCDH15; USH1F

STAG2

10735

Q8N3U4

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SA2/STAG2 recombinant protein (Position: E750-M1175) .

Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney. CD1 isoforms, such as isoform 1, have a limited pattern of expression and is detected in testis, retina and cochlea. CD2 isoforms, such as isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen, testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely expressed.

Flow Cytometry

Cancer Susceptibility, Epigenetics and Nuclear Signaling, Transcription, Tumor Suppressors

Immunogen affinity purified.

Liquid

Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.

1. Aoi, H., Lei, M., Mizuguchi, T., Nishioka, N., Goto, T., Miyama, S., Suzuki, T., Iwama, K., Uchiyama, Y., Mitsuhashi, S., Itakura, A., Takeda, S., Matsumoto, N. Nonsense variants in STAG2 result in distinct sex-dependent phenotypes. J. Hum. Genet. 64: 487-492, 2019. Note: Retraction: J. Hum. Genet. 65: 811 only, 2020. 2. Balbas-Martinez, C., Sagrera, A., Carrillo-de-Santa-Pau, E., Earl, J., Marquez, M., Vazquez, M., Lapi, E., Castro-Giner, F., Beltran, S., Bayes, M., Carrato, A., Cigudosa, J. C., and 21 others. Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nature Genet. 45: 1464-1469, 2013. 3. Carramolino, L., Lee, B. C., Zaballos. A., Peled, A., Barthelemy, I., Shav-Tal, Y., Prieto, I., Carmi, P., Gothelf, Y., Gonzalez de Buitrago, G., Aracil, M., Marquez, G., Barbero, J. L., Zipori, D. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. Gene 195: 151-159, 1997. Note: Erratum: Gene 206: 283 only, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

28461 MW

6

Protocadherin related 15

Cell membrane. Single-pass type I. membrane protein. Secreted.

Breast cancer metastasis-suppressor 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.