Anti-Sam68/KHDRBS1 Antibody Picoband® fluoro550 Vervoeging

KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene. This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants.

Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; CDw119; CD119; IFNGR1

KHDRBS1

10657

Q07666

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Sam68/KHDRBS1 recombinant protein (Position: M21-E239) .

Liver and small intestine. Also found in ovary, testis and kidney.

Flow Cytometry

Antiviral Signaling, Cytokines, Hematopoietic Progenitors, Host-Virus Interaction, Immune System Diseases, Immunology, Innate Immunity, Interferons, Interspecies Interaction, Lymphoid, Macrophage/Inflammation, Microbiology, Myeloid, Stem Cells, Surface Molecules, T Lymphocytic Lineage

Immunogen affinity purified.

Liquid

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460) . Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114) . .

1. Barlat, I., Maurier, F., Duchesne, M., Guitard, E., Tocque, B., Schweighoffer, F. A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain. J. Biol. Chem. 272: 3129-3132, 1997. 2. Bianchi, E., Barbagallo, F., Valeri, C., Geremia, R., Salustri, A., De Felici, M., Sette, C. Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development. Hum. Molec. Genet. 19: 4886-4894, 2010. 3. Carlosama, C., Patino, L. C., Beau, I., Morel, A., Delemer, B., Young, J., Binart, N., Laissue, P. A novel mutation in KHDRBS1 in a patient affected by primary ovarian insufficiency. (Letter) Clin. Endocr. 89: 245-246, 2018.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

54405 MW

6

Interferon gamma receptor 1

Cell membrane ; Single-pass type I membrane protein .

Interferon gamma receptor 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.