Anti-SAMSN SAMSN1 Antilichaam

SAMSN (HACS1) is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains. It encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and malignancies including myeloid leukemia, lymphoma, and myeloma. SAMSN has restricted expression in human tissues. It has been shown to be up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. SAMSN is an immunoinhibitory adaptor that might be a useful target for immune suppression therapy.

Boster Bio Anti-SAMSN SAMSN1 Antibody (Catalog # A08977) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.

SLy2, HACS1, NASH1, SASH2, SH3D6B, SAM domain-containing protein SAMSN-1, Hematopoietic adaptor containing SH3 and SAM domains 1

SAMSN1

Q9NSI8

Human

At least two isoforms of SAMSN are known to exist.

Rabbit polyclonal SAMSN antibody was raised against an 18 amino acid peptide near the carboxy terminus of human SAMSN. The immunogen is located within the last 50 amino acids of SAMSN.

Detected in peripheral blood B-cells (at protein level) . Detected in spleen, liver and peripheral blood.

ELISA, WB, ICC, IF

Immunology

SAMSN Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro) . Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity) .

SAMSN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A08977

41708 MW

SAM domain, SH3 domain and nuclear localization signals 1

Nucleus

Mouse

SAM domain, SH3 domain and nuclear localization signals 1

IgG

SAMSN Antibody is supplied in PBS containing 0.02% sodium azide.