Anti-SAP18 Antibody Picoband® 0,00647 Vervoeging

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene. Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein ly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.

Rho-related GTP-binding protein Rho6; Rho family GTPase 1; Rnd1; RND1; RHO6

SAP18

10284

O00422

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SAP18 recombinant protein (Position: M1-Y153) .

Mostly expressed in brain and liver.

Flow Cytometry

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, G Protein Signaling, Microfilaments, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins

Immunogen affinity purified.

Liquid

Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. .

1. Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., Reinberg, D. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89: 357-364, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

26056 MW

6

Rho-related GTP-binding protein Rho6

Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytoskeleton .

AP-2 complex subunit mu

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.