Anti-SATB2 Antibody Picoband® 0,00647 Vervoeging

Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.

Phospholipase D2; PLD 2; hPLD2; Choline phosphatase 2; PLD1C; Phosphatidylcholine-hydrolyzing phospholipase D2; PLD2

SATB2

23314

Q9UPW6

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence in the middle region of human SATB2, identical to the related mouse sequences.

Widely expressed.

Flow Cytometry

Adaptive Immunity, Autoimmune, B Cells, Cell Type Markers, Cytokines, Immune System Diseases, Immunology, Innate Immunity, T Cells, TNF Superfamily

Immunogen affinity purified.

Liquid

May have a role in signal-induced cytoskeletal regulation and/or endocytosis.

1. Bengani, H., Handley, M., Alvi, M., Ibitoye, R., Lees, M., Lynch, S. A., Lam, W., Fannemel, M., Nordgren, A., Malmgren, H., Kvarnung, M., Mehta, S., and 22 others. Clinical and molecular consequences of disease-associated de novo mutations in SATB2. Genet Med. 19: 900-908, 2017. 2. Brewer, C. M., Leek, J. P., Green, A. J., Holloway, S., Bonthron, D. T., Markham, A. F., FitzPatrick, D. R. A locus for isolated cleft palate, located on human chromosome 2q32. Am. J. Hum. Genet. 65: 387-396, 1999. 3. Britanova, O., Depew, M. J., Schwark, M., Thomas, B. L., Miletich, I., Sharpe, P., Tarabykin, V. Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. Am. J. Hum. Genet. 79: 668-678, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Phospholipase D2

Membrane. Peripheral membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.