Anti-SBP/SELENBP1 Antibody Picoband® fluoro647 Vervoeging

Selenium-binding protein 1, also known as SELENBP1 or SBP is a protein that in humans is encoded by the SLELNBP1 gene. This gene is mapped to 1q21.3. This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation.

Selenium-binding protein 1;56 kDa selenium-binding protein; SBP56; SP56; SELENBP1; SBP

SELENBP1

8991

Q13228

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human Selenium Binding Protein 1.

Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level) . Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients. .

Flow Cytometry

Cancer, Cofactors, Vitamins/Minerals, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Oncoproteins/Suppressors, Pathways and Processes, Signal Transduction, Tumor Suppressors, Vitamins/Minerals

Immunogen affinity purified.

Liquid

Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity) . .

1. Chang, P. W. G., Tsui, S. K. W., Liew, C., Lee, C., Waye, M. M. Y., Fung, K. Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. J. Cell. Biochem. 64: 217-224, 1997. 2. Okunuki, Y., Usui, Y., Takeuchi, M., Kezuka, T., Hattori, T., Masuko, K., Nakamura, H., Yudoh, K., Usui, M., Nishioka, K., Kato, T. Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease. Exp. Eye Res. 84: 823-831, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

52391 MW

No cross reactivity with other proteins.

6

Selenium-binding protein 1

Nucleus. Cytoplasm, cytosol. Membrane ; Peripheral membrane protein . May associate with Golgi membrane. May associate with the membrane of autophagosomes (By similarity) . .

Belongs to the PIAS family.

Selenium-binding protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.