Anti-SCFD2 Antibody Picoband® 0,00647 Vervoeging

SCFD2 (sec1 family domain containing 2), also known as STXBP1L1 (syntaxinbinding protein 1-like 1), is a 684 amino acid protein suggested to play a role in protein transport. Existing as two alternatively spliced isoforms, SCFD2 is a member of the STXBP/unc-18/SEC1 family and is encoded by a gene that maps to human chromosome 4q12. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington’s disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

SCFD2

152579

Q8WU76

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human SCFD2 recombinant protein (Position: K20-H585) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Mitobe, Y. , Iino, K. , Takayama, K. , Ikeda, K. , Suzuki, T. , & Aogi, K. , et al. (2020) . Psf promotes er-positive breast cancer progression via posttranscriptional regulation of esr1 and scfd2. Cancer research, 80 (11), 2230-2242. 2. Takeiwa, T. , Ikeda, K. , Suzuki, T. , Sato, W. , Iino, K. , & Mitobe, Y. , et al. (2022) . Pspc1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates rna processing of esr1 and scfd2. Scientific reports, 12 (1), 9495. 3. (2010) . Genome-wide association identifies atoh7 as a major gene determining human optic disc size. Human Molecular Genetics, 19 (13), 2716.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.