Anti-SCNM1 Antibody Picoband® 31.0647 Vervoeging

SCNM1 is a zinc finger protein and putative splicing factor. In mice, Scnm1 modifies phenotypic expression of Scn8a (MIM 600702) mutations.

SCNM1

79005

Q9BWG6

Human, Mouse, Rat

E.coli-derived human SCNM1 recombinant protein (Position: D8-D230) . Human SCNM1 shares 82.1% amino acid (aa) sequence identity with mouse SCNM1.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Buchner, D. A., Trudeau, M., Meisler, M. H. SCNM1, a putative RNA splicing factor that modifies disease severity in mice. Science 301: 967-969, 2003. 2. Howell, V. M., Jones, J. M., Bergren, S. K., Li, L., Billi, A. C., Avenarius, M. R., Meisler, M. H. Evidence for a direct role of the disease modifier SCNM1 in splicing. Hum. Molec. Genet. 16: 2506-2516, 2007. 3. Iturrate, A., Rivera-Barahona, A., Flores, C. L., Otaify, G. A., Elhossini, R., Perez-Sanz, M. L., Nevado, J., Tenorio-Castano, J., Trivino, J. C., Garcia-Gonzalo, F. R., Piceci-Sparascio, F., De Luca, A., Martinez, L., Kalayci, T., Lapunzina, P., Altunoglu, U., Aglan, M., Abdalla, E., Ruiz-Perez, V. L. Mutations in SCNM1 cause orofaciodigital syndrome due to minor intron splicing defects affecting primary cilia. Am. J. Hum. Genet. 109: 1828-1849, 2022.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

26 KDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.