Anti-SCUBE3 Antilichaam

SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart (1,2) . Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand (3,4) and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta1, VEGF, Snail, and Slug.

Boster Bio Anti-SCUBE3 Antibody (Catalog # A09090) . Tested in ELISA, IHC-P applications. This antibody reacts with Human.

CEGF3, CEGF3, Signal peptide, CUB and EGF-like domain-containing protein 3

SCUBE3

Q8IX30

Human

SCUBE3 antibody was raised against a 15 amino acid peptide near the center of human SCUBE3. The immunogen is located within amino acids 440 - 490 of SCUBE3.

Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.

ELISA, IHC-P

Signal Transduction

SCUBE3 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.

SCUBE3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

https://www.bosterbio.com/msds?sku=A09090

109282 MW

Signal peptide, CUB and EGF-like domain-containing protein 3 precursor

Secreted

Signal peptide, CUB and EGF-like domain-containing protein 3 precursor

IgG

SCUBE3 Antibody is supplied in PBS containing 0.02% sodium azide.