Anti-SCYL2 Antibody Picoband® fluoro488 Vervoeging

SCY1-like protein 2 is a protein that in humans is encoded by the SCYL2 gene. The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene.

Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein; GJC1; GJA7

SCYL2

55681

Q6P3W7

Human

No cross-reactivity with other proteins

E.coli-derived human SCYL2 recombinant protein (Position: E208-Q909) .

Ubiquitously expressed.

Flow Cytometry

Cell Adhesion, Cytoskeleton/ECM, Signal Transduction

Immunogen affinity purified.

Liquid

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

1. Conner, S. D., Schmid, S. L. CVAK104 is a novel poly (L) -lysine-stimulated kinase that targets the beta-2-subunit of AP2. J. Biol. Chem. 280: 21539-21544, 2005. 2. Gingras, S., Earls, L. R., Howell, S., Smeyne, R. J., Zakharenko, S. S., Pelletier, S. SCYL2 protects CA3 pyramidal neurons from excitotoxicity during functional maturation of the mouse hippocampus. J. Neurosci. 35: 10510-10522, 2015. 3. Gross, M. B. Personal Communication. Baltimore, Md. 5/15/2015.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

45470 MW

6

Gap junction gamma-1 protein

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Gap junction gamma-1 protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.