Anti-SDCCAG1/NEMF Antilichaam Picoband® 31.0550 Vervoeging

Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene. This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor.

Tudor domain-containing protein 3; TDRD3

NEMF

9147

O60524

Human

No cross-reactivity with other proteins.

E.coli-derived human SDCCAG1/NEMF recombinant protein (Position: H81-R607) .

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Flow Cytometry

Adaptive Immunity, B Cells, Immunoglobulins, Immunology

Immunogen affinity purified.

Liquid

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

1. Ahmed, A., Wang, M., Bergant, G., Maroofian, R., Zhao, R., Alfadhel, M., Nashabat, M., AlRifai, M. T., Eyaid, W., Alswaid, A., Beetz, C., Qin, Y., and 21 others. Biallelic loss-of-function variants in NEMF cause central nervous system impairment and axonal polyneuropathy. Hum. Genet. 140: 579-592, 2021. 2. Anazi, S., Maddirevula, S., Faqeih, E., Alsedairy, H., Alzahrani, F., Shamseldin, H. E., Patel, N., Hashem, M., Ibrahim, N., Abdulwahab, F., Ewida, N., Alsaif, H. S., and 36 others. Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield. Molec. Psychiat. 22: 615-624, 2017. 3. Carbonnelle, D., Liehr, T., Jacquot, C., Masson, D., Lustenberger, P., Denis, M. G., Roussakis, C. Assignment of the serologically defined colon cancer antigen 1 gene (SDCCAG1) to human chromosome band 14q22 by in situ hybridization. Cytogenet. Cell Genet. 86: 248-249, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Tudor domain containing 3

Nucleus. Cytoplasm.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.