Anti-SDE2 Antibody Picoband®

Enables damaged DNA binding activity. Involved in several processes, including cellular response to UV; mitotic G1 DNA damage checkpoint signaling; and protein ubiquitination. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck.

Boster Bio Anti-SDE2 Antibody Picoband® catalog # A15473-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

SDE2

163859

Q6IQ49

Human

No cross-reactivity with other proteins.

E.coli-derived human SDE2 recombinant protein (Position: I10-K447) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

ELISA, Flow Cytometry, IF, IHC, ICC, WB

Cell Biology

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Jess, F. , Anqi, D. , Abigail, M. , Alexandra, M. M. , Neilj, G. , & Daniel, C. , et al. Sde2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Research (16), 16. 2. Rageul, J. , Park, J. J. , Zeng, P. P. , Lee, E. A. , & Kim, H. . Sde2 integrates into the timeless-tipin complex to protect stalled replication forks. Nature Communications. 3. Julie, R. , Park, J. J. , Ukhyun, J. , Weinheimer, A. S. , Vu, T. T. M. , & Hyungjin, K. . (2019) . Conditional degradation of sde2 by the arg/n-end rule pathway regulates stress response at replication forks. Nuclc Acids Research (8), 8.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A15473-1

24145 MW

54 kDa

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.