Anti-SDHA Antibody Picoband®

SDHA (Succinate dehydrogenase complex, subunit a, flavoprotein), also called SDH1, HOMOLOG OF, is a protein that in humans is encoded by the SDHA gene. The SDHA gene is mapped on 5p15.33. The SDHA gene is highly polymorphic. The gene that codes for the SDHA protein is nuclear, even though the protein is located in the inner membrane of the mitochondria. Heterozygous carriers of an SDHA mutation do not developparagangliomas as has been seen for mutations in the other subunits. In vitro functional expression studies in the yeast homolog showed that the mutation resulted in a loss of SDH activity and rendered the mutant SDHA protein more susceptible to proteolysis. The findings indicated that SDHA, like other SDH subunits, can act as a tumor suppressor gene.

Boster Bio Anti-SDHA Antibody catalog # PA1717. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial;1.3.5.1; Flavoprotein subunit of complex II; Fp; SDHA; SDH2, SDHF

SDHA

6389

P31040

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human SDHA, identical to the related rat and mouse sequences.

Wide tissue distribution. Undetectable in placental tissue.

Flow Cytometry, IHC, WB

Mitochondria, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Organelles, Oxidative Phosphorylation, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) . Can act as a tumor suppressor. .

1. DiMauro, S., Schon, E. A. Nuclear power and mitochondrial disease. Nature Genet. 19: 214-215, 1998. 2. Hirawake, H., Wang, H., Kuramochi, T., Kojima, S., Kita, K. Human complex II (succinate-ubiquinone oxidoreductase) : cDNA cloning of the flavoprotein (Fp) subunit of liver mitochondria. J. Biochem. 116: 221-227, 1994. 3. Morris, A. A. M., Farnsworth, L., Ackrell, B. A. C., Turnbull, D. M., Birch-Machin, M. A. The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase. Biochim. Biophys. Acta 1185: 125-128, 1994.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=PA1717

72692 MW

72 kDa

No cross reactivity with other proteins.

6

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.