Anti-SEC24A Antibody Picoband® 0,00647 Vervoeging

SEC24 family, member A (S. cerevisiae) is a protein that in humans is encoded by the SEC24A gene. The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII) -coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3; SLC7A3; ATRC3, CAT3

SEC24A

10802

O95486

Human, Monkey

No cross-reactivity with other proteins.

E.coli-derived human SEC24A recombinant protein (Position: Q43-Q1045) .

Highly expressed in thymus, uterus and testis. Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen. In brain, highest expression in thalamus, hippocampus and amygdala. .

Flow Cytometry

Amino Acid Metabolism, Amino Acids, Cancer, Channels, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. .

1. Pagano, A., Letourneur, F., Garcia-Estefania, D., Carpentier, J.-L., Orci, L., Paccaud, J.-P. Sec24 proteins and sorting at the endoplasmic reticulum. J. Biol. Chem. 274: 7833-7844, 1999. 2. Tang, B. L., Kausalya, J., Low, D. Y. H., Lock, M. L., Hong, W. A family of mammalian proteins homologous to yeast Sec24p. Biochem. Biophys. Res. Commun. 258: 679-684, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67169 MW

6

Cationic amino acid transporter 3

Cell membrane; Multi-pass membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.