Anti-SEMA3D Antibody Picoband® 0,00647 Vervoeging

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development.

Nck-associated protein 1; NAP 1; Membrane-associated protein HEM-2; p125Nap1; NCKAP1; HEM2, KIAA0587, NAP1

SEMA3D

223117

O95025

Human

No cross-reactivity with other proteins.

E.coli-derived human SEMA3D recombinant protein (Position: D88-H697) .

Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.

Flow Cytometry

Neurogenesis, Neurology Process, Neuroscience, NFKB Pathway, Nuclear Signaling, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.

1. Jin, Z., Chau, M. D., Bao, Z.-Z. Sema3D, Sema3F, and Sema5A are expressed in overlapping and distinct patterns in chick embryonic heart. Dev. Dyn. 235: 163-169, 2006. 2. Liu, Y., Halloran, M. C. Central and peripheral axon branches from one neuron are guided differentially by semaphorin3D and transient axonal glycoprotein-1. J. Neurosci. 25: 10556-10563, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

128790 MW

6

Nck-associated protein 1

Cell membrane ; Single-pass membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Single-pass membrane protein ; Cytoplasmic side . At the interface between the lamellipodial actin meshwork and the membrane. .

Nck-associated protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.