Anti-SEPTIN12 Antibody Picoband® 31.0550 Vervoeging

Septin 12 is a protein that in humans is encoded by the SEPT12 gene. This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.

Mitochondrial import inner membrane translocase subunit Tim17-A; Inner membrane preprotein translocase Tim17a; TIMM17A; MIMT17; TIM17; TIM17A; TIMM17

SEPTIN12

124404

Q8IYM1

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SEPTIN12 recombinant protein (Position: K71-F358) .

Flow Cytometry

Cancer, Metabolism, Mitochondrial Metabolism, Organelle Proteins, Pathways and Processes, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Immunogen affinity purified.

Liquid

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

1. Hall, P. A., Jung, K., Hillan, K. J., Russell, S. E. H. Expression profiling the human septin gene family. J. Path. 206: 269-278, 2005. 2. Kuo, Y.-C., Lin, Y.-H., Chen, H.-I., Wang, Y.-Y., Chiou, Y.-W., Lin, H.-H., Pan, H.-A., Wu, C.-M., Su, S.-M., Hsu, C.-C., Kuo, P.-L. SEPT12 mutations cause male infertility with defective sperm annulus. Hum. Mutat. 33: 710-719, 2012. 3. Lin, Y.-H., Chou, C.-K., Hung, Y.-C., Yu, I.-S., Pan, H.-A., Lin, S.-W., Kuo, P.-L. SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos. Fertil. Steril. 95: 363-365, 2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Translocase of inner mitochondrial membrane 17A

Mitochondrion inner membrane, Multi-pass membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.