Anti-Serine racemase/SRR Antibody Picoband® fluoro594 Vervoeging

SRR (serine racemase) is a 37 kDa protein and belongs to the serine/threonine dehydratase family. It plays a role in neuronal activity and a potential biological role in the regulation of N-methyl-D-aspartate (NMDA) receptor activity in these peripheral organs as well. SRR catalyzes the racemization between l- and d-serine.

Dermatopontin; Tyrosine-rich acidic matrix protein; TRAMP; DPT

SRR

63826

Q9GZT4

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Serine racemase/SRR recombinant protein (Position: A3-E283) .

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.

Flow Cytometry

Biochemicals, Chemical Type, Signal Transduction

Immunogen affinity purified.

Liquid

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity) .

1. De Miranda, J., Santoro, A., Engelender, S., Wolosker, H. Human serine racemase: molecular cloning, genomic organization and functional analysis. Gene 256: 183-188, 2000. 2. Henneberger, C., Papouin, T., Oliet, S. H. R., Rusakov, D. A. Long-term potentiation depends on release of D-serine from astrocytes. Nature 463: 232-236, 2010. 3. Labrie, V., Fukumura, R., Rastogi, A., Fick, L. J., Wang, W., Boutros, P. C., Kennedy, J. L., Semeralul, M. O., Lee, F. H., Baker, G. B., Belsham, D. D., Barger, S. W., Gondo, Y., Wong, A. H. C., Roder, J. C. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum. Molec. Genet. 18: 3227-3243, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

37 kDa

6

Dermatopontin

Secreted, extracellular space, extracellular matrix.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.