Anti-Seryl-tRNA synthetase/SERS/SARS1 Antibody Picoband® FLO7647 Vervoeging

This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown.

Transcription factor GATA-4; GATA-binding factor 4; GATA4

SARS1

6301

P49591

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human Seryl-tRNA synthetase/SERS/SARS1 recombinant protein (Position: K71-K483) .

Widely expressed in hematopoietic cells. Expressed in neutrophils. Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells.

Flow Cytometry

Cardiovascular, Cytochromes, Drug Metabolism, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724) . In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724) . Involved in bone morphogenetic protein (BMP) -mediated induction of cardiac- specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity) . Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity) . Promotes cardiac myocyte enlargement (PubMed:20081228) . Required during testicular development (PubMed:21220346) . May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735) .

1. Fukui, H., Hanaoka, R., Kawahara, A. Noncanonical activity of seryl-tRNA synthetase is involved in vascular development. Circ. Res. 104: 1253-1259, 2009. 2. Herzog, W., Muller, K., Huisken, J., Stainier, D. Y. R. Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. Circ. Res. 104: 1260-1266, 2009. Note: Erratum: Circ. Res. 105: e54 only, 2009. 3. Lo, W.-S., Gardiner, E., Xu, Z., Lau, C.-F., Wang, F., Zhou, J. J., Mendlein, J. D., Nangle, L. A., Chiang, K. P., Yang, X.-L., Au, K.-F., Wong, W. H., Guo, M., Zhang, M., Schimmel, P. Human tRNA synthetase catalytic nulls with diverse functions. Science 345: 328-332, 2014.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

44565 MW

6

Transcription factor GATA-4

Nucleus

Transcription factor GATA-4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.