Anti-SESN1 Antibody Picoband® fluoro488 Vervoeging

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Dynein light chain Tctex-type 1; Protein CW-1; T-complex testis-specific protein 1 homolog; DYNLT1; TCTEL1; TCTEX-1; TCTEX1

SESN1

27244

Q9Y6P5

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SESN1 recombinant protein (Position: M1-A275) .

Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level) .

Flow Cytometry

Cytoskeleton, Cytoskeleton/ECM, Dynein, Host-Virus Interaction, Interspecies Interaction, Microbiology, Motor Proteins, Signal Transduction

Immunogen affinity purified.

Liquid

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.

1. Buckbinder, L., Talbott, R., Seizinger, B. R., Kley, N. Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes. Proc. Nat. Acad. Sci. 91: 10640-10644, 1994. 2. Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., Chumakov, P. M. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304: 596-600, 2004. 3. Cangelosi, A. L., Puszynska, A. M., Roberts, J. M., Armani, A., Nguyen, T. P., Spinelli, J. B., Kunchok, T., Wang, B., Chan, S. H., Lewis, C. A., Comb, W. C., Bell, G. W., Helman, A., Sabatini, D. M. Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. Science 377: 47-56, 2022.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

48608 MW

6

Dynein light chain Tctex-type 1

Golgi apparatus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Localizes to mitotic spindles.

Serine protease HTRA3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.