Anti-SET Monoklonale Antilichaam

Boster Bio Anti-SET Monoclonal Antibody catalog # M02211. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Caspase-10; CASP-10;3.4.22.63; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; Caspase-10 subunit p23/17; Caspase-10 subunit p12; CASP10; MCH4

SET

6418

Q01105

Human, Mouse, Rat

A synthesized peptide derived from human SET Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1.

Clone: AEEO-19

Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

WB, IHC, ICC, IF, IP, Flow Cytometry

Adaptive Immunity, Alzheimer's Disease, Cancer, Cell Biology, Cell Cycle, Cell Division, Chromatin Remodeling, Chromosome Structure, Epigenetics and Nuclear Signaling, ER Proteins, Immunology, Neurodegenerative Disease, Neurology Process, Neuroscience, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Protein Trafficking, Ser/Thr Phosphatases, Signal Transduction, T Cells

Affinity-chromatography

0.5mg/ml

Liquid

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M02211

58951 MW

80 kDa

Caspase-10

Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity) . .

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.