Anti-SF3A2 Antibody Picoband® 0,00647 Vervoeging

Splicing factor 3A subunit 2 is a protein that in humans is encoded by the SF3A2 gene. This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.

Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7

SF3A2

8175

Q15428

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SF3A2 recombinant protein (Position: R29-P256) .

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins

Immunogen affinity purified.

Liquid

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .

1. Bennett, M., Reed, R. Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. Science 262: 105-108, 1993. 2. Dresser, D. W., Hacker, A., Lovell-Badge, R., Guerrier, D. The genes for a spliceosome protein (SAP62) and the anti-mullerian hormone (AMH) are contiguous. Hum. Molec. Genet. 4: 1613-1618, 1995. 3. Dresser, D. W., Jamin, S. P., Atkins, C. J., Guerrier, D. An expressed GNRP-like gene shares a bi-ional promoter with SF3A2 (SAP62) immediately upstream of AMH. Gene 277: 163-173, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Interleukin 17B

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.