Anti-SF3A3 Antibody Picoband®

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene. This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants

Boster Bio Anti-SF3A3 Antibody Picoband® catalog # A10671-1. Tested in ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

RNA-binding protein Nova-2; Astrocytic NOVA1-like RNA-binding protein; Neuro-oncological ventral antigen 2; NOVA2; ANOVA; NOVA3

SF3A3

10946

Q12874

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SF3A3 recombinant protein (Position: E123-Q472) .

Brain. Expression restricted to astrocytes.

WB, IHC, ICC, IF, IP, Flow Cytometry, ELISA

Channels, Metabolism, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

May regulate RNA splicing or metabolism in a specific subset of developing neurons. Binds single strand RNA.

1. Chiara, M. D., Champion-Arnaud, P., Buvoli, M., Nadal-Ginard, B., Reed, R. Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. Proc. Nat. Acad. Sci. 91: 6403-6407, 1994. 2. Gross, M. B. Personal Communication. Baltimore, Md. 4/4/2014. 3. Kramer, A., Legrain, P., Mulhauser, F., Groning, K., Brosi, R., Bilbe, G. Splicing factor SF3a60 is the mammalian homologue of PRP9 of S. cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivo. Nucleic Acids Res. 22: 5223-5228, 1994.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A10671-1

29370 MW

59 kDa

6

NOVA alternative splicing regulator 2

Nucleus.

Aquaporin-6

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.