Anti-SFXN3 Antibody Picoband® fluoro488 Vervoeging

SFXN3, a mitochondrial membrane protein, is a member of sideroflexin family. Serum anti-SFXN3 autoantibody was elevated in early stage of the oral squamous cell carcinoma significantly, indicating its clinical value for diagnosis of oral squamous cell carcinoma.

DAP3-binding cell death enhancer 1; Death ligand signal enhancer; DELE1; DELE; KIAA0141

SFXN3

81855

Q9BWM7

Human

No cross-reactivity with other proteins.

E.coli-derived human SFXN3 recombinant protein (Position: D32-L321) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

1. Fleming, M. D., Campagna, D. R., Haslett, J. N., Trenor, C. C., III, Andrews, N. C. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev. 15: 652-657, 2001. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 12/17/2013. 3. Kory, N., Wyant, G. A., Prakash, G., iut de Bos, J., Bottanelli, F., Pacold, M. E., Chan, S. H., Lewis, C. A., Wang, T., Keys, H. R., Guo, Y. E., Sabatini, D. M. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science 362: eaat9528, 2018. Note: Electronic Article.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

DAP3 binding cell death enhancer 1

Mitochondrion.

DAP3 binding cell death enhancer 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.