Anti-SFXN5 Antibody Picoband®

Sideroflexin 5 gene (SFXN5) is located on human chromosome 2p13.2. SFXN5 protein is broadly expressed in brain, liver, kidney and other tissues. The SFXN5 (also known as BBG-TCC; SLC56A5) gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, etc. SFXN5 protein has cation transmembrane transporter activity and citrate transmembrane transporter activity. SFXN5 is associated with Parkinson Disease.An important paralog of this gene is SFXN3.

Boster Bio Anti-SFXN5 Antibody Picoband® catalog # A15698-1. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

SFXN5

94097

Q8TD22

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SFXN5 recombinant protein (Position: Q34-L340) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

WB, IHC, Flow Cytometry, ELISA

Cell Biology

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Fleming, M. D., Campagna, D. R., Haslett, J. N., Trenor, C. C., III, Andrews, N. C. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev. 15: :652-657, 2001. 2. Lockhart, P. J., Holtom, B., Lincoln, S., Hussey, J., Zimprich, A., Gasser, T., Wszolek, Z. K., Hardy, J., Farrer, M. J. The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3. Gene 285: 229-237, 2002. 3. Miyake, S., Yamashita, T., Taniguchi, M., Tamatani, M., Sato, K., Tohyama, M. Identification and characterization of a novel mitochondrial tricarboxylate carrier. Biochem. Biophys. Res. Commun. 295: 463-468, 2002.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A15698-1

24145 MW

37 kDa

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.