Anti-SGLT1/SLC5A1 Antibody Picoband® fluoro488 Vervoeging

Sodium/glucose cotransporter 1 (SLC5A1), also known as NAGT or SGLT1 is a protein that in humans is encoded by the SLC5A1 gene. This gene is mapped to 22q12.3. This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene.

Sodium/glucose cotransporter 1; Na (+) /glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1; SLC5A1; NAGT, SGLT1

SLC5A1

6523

P13866

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of mouse SGLT1, different from the related rat sequence by one amino acid, and from the related human sequence by two amino acids.

Expressed mainly in intestine and kidney.

Flow Cytometry

Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Actively transports glucose into cells by Na (+) cotransport with a Na (+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na (+) /glucose cotransporter arranged in series along kidney proximal tubules.

1. Margolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., Shirazi-Beechey, S. P. T1R3 and gustducin in gut sense sugars to regulate expression of Na (+) -glucose cotransporter 1. Proc. Nat. Acad. Sci. 104: 15075-15080, 2007. 2. Turk, E, Wright, E. M. Membrane topology motifs in the SGLT cotransporter family. J. Membr. Biol. 159: 1-20, 1997. 3. Wright, E. M., Turk, E., Zabel, B., Mundlos, S., Dyer, J. Molecular genetics of intestinal glucose transport. J. Clin. Invest. 88: 1435-1440, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

73498 MW

No cross reactivity with other proteins.

6

Sodium/glucose cotransporter 1

Membrane; Multi-pass membrane protein.

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

Sodium/glucose cotransporter 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.