Anti-SGOL2 SGO2 Antilichaam

Boster Bio Anti-SGOL2 SGO2 Antibody (Catalog# A30763) . Tested in IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

SGOL2; Shugoshin-like 2; Shugoshin-2; Sgo2; Tripin

SGO2

Q562F6

Human, Mouse, Rat

A peptide derived from human SGOL2. Immunogen sequence location: 681 - 730

IHC, ICC, IF, ELISA

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Liquid

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity) . Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A30763

144739 MW

Shugoshin 2

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity) . SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity) . During meiosis II, it shows a striking tension- dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity) . In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487) . Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487) .

Rabbit IgG

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.