Anti-SGTA Antibody Picoband® 0,00647 Vervoeging

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene. This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.

SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2; UBA2; SAE2; UBLE1B; HRIHFB2115

SGTA

6449

O43765

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SGTA recombinant protein (Position: M1-Q282) .

Duodenum, heart, lung and liver, but not thymus.

Flow Cytometry

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin

Immunogen affinity purified.

Liquid

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

1. Kordes, E., Savelyeva, L., Schwab, M., Rommelaere, J., Jauniaux, J.-C., Cziepluch, C. Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. Genomics 52: 90-94, 1998. 2. Shao, S., Rodrigo-Brenni, M. C., Kivlen, M. H., Hegde, R. S. Mechanistic basis for a molecular triage reaction. Science 355: 298-302, 2017. 3. Tobaben, S., Thakur, P., Fernandez-Chacon, R., Sudhof, T. C., Rettig, J., Stahl, B. A trimeric protein complex functions as a synaptic chaperone machine. Neuron 31: 987-999, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64133 MW

6

Ubiquitin like modifier activating enzyme 2

Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

Heterogeneous nuclear ribonucleoprotein L

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.