Anti-SHARPIN Antibody Picoband®

Enables polyubiquitin modification-dependent protein binding activity. Involved in defense response to bacterium; protein linear polyubiquitination; and regulation of signal transduction. Located in cytosol. Part of LUBAC complex.

Boster Bio Anti-SHARPIN Antibody Picoband® catalog # A06687-2. Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

SHARPIN; SIPL1; PSEC0216; Sharpin; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; hSIPL1

SHARPIN

81858

Q9H0F6

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human SHARPIN recombinant protein (Position: H25-R325) . Human SHARPIN shares 72.3% and 72.6% amino acid (aa) sequence identity with mouse and rat SHARPIN, respectively.

WB, IHC, Flow Cytometry, ELISA

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

1. Ang, R. L., Chan, M., Legarda, D., Sundberg, J. P., Sun, S. C., Gillespie, V. L., Chun, N., Heeger, P. S., Xiong, H., Lira, S. A., Ting, A. T. Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death. Proc. Nat. Acad. Sci. 118: e2001602118, 2021. 2. Daigo, Y., Takayama, I., Ward, S. M., Sanders, K. M., Fujino, M. A. Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/W (v) mouse. J. Gastroent. Hepatol. 18: 712-718, 2003. 3. Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W.-L., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A. W., Silke, J., Walczak, H. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471: 591-596, 2011.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A06687-2

40 kDa

40 kDa

6

SHANK associated RH domain interactor

Sharpin

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.