Anti-ShcA-antilichaam

The adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then, a number of studies in multiple systems have implicated a role for Shc in many different types of signal transduction including growth factor, antigen, cytokine, G-protein, hormone, and integrin receptor signaling. In addition to the ubiquitous ShcA, there are two other shc gene products, ShcB and ShcC, which are predominantly expressed in neuronal cells. ShcA knockout mice are embryonic lethal and have clearly suggested an important role for ShcA in vivo. An important role for Shc in the activation of MAPK pathway has been established. Thus, Shc adapter proteins are critical components of signal transduction pathways involved in many different cellular processes.

Our ShcA primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, rabbit, and rat ShcA and is antigen affinity purified. It is great for use in ELISA, WB, ICC.

Our ShcA primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, rabbit, and rat ShcA and is antigen affinity purified. It is great for use in WB, ICC.

SH2 C1, SHC

SHC1

P29353

Human, Mouse, Rabbit, and Rat

A recombinant protein that included amino acid residues within the C-terminal region of human ShcA. This sequence has high homology with similar regions in rat and mouse ShcA.

ShcA

Unconjugated

ELISA, WB, ICC

Cell Signaling, Neurodegenerative Disease, Alzheimer's Disease, Oncoproteins

Antigen Affinity Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

45/52/66

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Affinity purified rabbit serum

1:1000

The antibody detects 46/52/66 kDa* bands corresponding to the molecular weight of ShcA variants on SDS-PAGE immunoblots of A431 cells. It also detects ShcA in human Jurkat, HeLa, and SKN-SH cells, as well as rat brain tissue and rabbit spleen fibroblasts.

1:50

Western blots performed on each lot.

Rabbit

Liquid

IgG

Human

Quality Control: WB

AB_2188007