Anti-SHROOM4 Antibody Picoband® 310647 Vervoeging

This gene encodes a member of the APX/Shroom family, which contain an N-terminal PDZ domain and a C-terminal ASD2 motif. The encoded protein may play a role in cytoskeletal architecture. Mutations in this gene have been linked to the X-linked Stocco dos Santos syndrome characterized by cognitive disabilities. Alternatively spliced transcript variants have been described.

Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7

SHROOM4

57477

Q9ULL8

Human

No cross-reactivity with other proteins.

E.coli-derived human SHROOM4 recombinant protein (Position: Y262-H928) .

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins

Immunogen affinity purified.

Liquid

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .

1. Hagens, O., Dubos, A., Abidi, F., Barbi, G., Van Zutven, L., Hoeltzenbein, M., Tommerup, N., Moraine, C., Fryns, J.-P., Chelly, J., van Bokhoven, H., Gecz, J., Dollfus, H., Ropers, H.-H., Schwartz, C. E., Stocco dos Santos, R. C., Kalscheuer, V., Hanauer, A. Disruptions of the novel KIAA1202 gene are associated with X-linked mental retardation. Hum. Genet. 118: 578-590, 2006. 2. Lopes, F., Barbosa, M., Ameur, A., Soares, G., de Sa, J., Dias, A. I., Oliveira, G., Cabral, P., Temudo, T., Calado, E., Cruz, I. F., Vieira, J. P., Oliveira, R., Esteves, S., Sauer, S., Jonasson, I., Syvanen, A.-C., Gyllensten, U., Pinto, D., Maciel, P. Identification of novel genetic causes of Rett syndrome-like phenotypes. J. Med. Genet. 53: 190-199, 2016. 3. Nagase, T., Ishikawa, K., Kikuno, R., Hirosawa, M., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 337-345, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Interleukin 17B

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.