Anti-SIGLEC6 Antilichaam

Siglec-6, originally identified on trophoblast cells of the placenta, is highly and consistently expressed on MCs from both mucosal and non-mucosal sites. Siglec-6 consists of 3 extracellular immunoglobulin (Ig) domains and 2 intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs), closely resembling the molecular structure of Siglec-3 (CD33) (PMID: 34289026) . Siglec-6 was recruited to placental expression during human evolution, presumably to interact with sialylated ligands for specific negative signaling functions and/or to regulate leptin availability (PMID: 17580316) . Siglec-6 is an immunoreceptor tyrosine-based inhibitory motif (ITIM) -bearing receptor selectively expressed by mast cells, making it a promising target for therapeutic intervention (PMID: 35406705) .

Boster Bio Anti-SIGLEC6 Antibody catalog # A10598-3. Tested in IHC, ELISA applications. This antibody reacts with Human.

SIGLEC6

O43699

Human

E.coli-derived human SIGLEC6 recombinant protein (Position: R18-D197) .

IHC, ELISA

Immunogen affinity purified.

500 μg/mL

Liquid

12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.

https://www.bosterbio.com/datasheet?sku=A10598-3

500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.