Anti-SIRT5/Sirtuin 5 Konijn Monoklonale Antilichaam

Boster Bio Anti-SIRT5/Sirtuin 5 Rabbit Monoclonal Antibody catalog # M02395. Tested in WB application. This antibody reacts with Human, Mouse.

NAD-dependent protein deacylase sirtuin-5, mitochondrial ;3.5.1.- ; Regulatory protein SIR2 homolog 5 ; SIR2-like protein 5 ; SIRT5 ; SIR2L5

SIRT5

23408

Q9NXA8

Human, Mouse

A synthesized peptide derived from human SIRT5

Clone: HHE-19

Widely expressed. .

WB

Acetylation, Cancer, Cardiovascular, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Metabolism

Affinity-chromatography

0.5mg/ml

Liquid

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693) . Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693) . Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062) . Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity) . Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M02395

33881 MW

60 kDa

NAD-dependent protein deacylase sirtuin-5, mitochondrial

Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.