Anti-SIRT6 Konijn Monoklonale Antilichaam

Boster Bio Anti-SIRT6 Rabbit Monoclonal Antibody catalog # M00611. Tested in WB application. This antibody reacts with Human.

NAD-dependent protein deacetylase sirtuin-6;3.5.1.-; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; SIRT6; SIR2L6

SIRT6

51548

Q8N6T7

Human

A synthesized peptide derived from human SIRT6

Clone: HBA-19

Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. .

WB

Acetylation, Apoptosis, Atherosclerosis, Cancer, Cardiovascular,2339, Chromatin Modifying Enzymes, Diabetes-associated, Epigenetics and Nuclear Signaling, Metabolism, NFKB Pathway, Nuclear Signaling Pathways, Obesity, Signal Transduction

Affinity-chromatography

0.5mg/ml

Liquid

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity) . Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD (+) in the absence of acetylated substrate. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00611

39119 MW

32-42 kDa, 65 kDa, 75 kDa

NAD-dependent protein deacetylase sirtuin-6

Nucleus, nucleoplasm . Predominantly nuclear. Associated with telomeric heterochromatin regions.

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.