Anti-SLC10A1/NTCP1 Antibody Picoband® fluoro488 Vervoeging

Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene. The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.

Sodium/bile acid cotransporter; Na (+) /bile acid cotransporter; Na (+) /taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1; Slc10a1; Ntcp

SLC10A1

6554

Q14973

Human, Mouse, Rat, Monkey

No cross-reactivity with other proteins.

E.coli-derived human SLC10A1/NTCP1 recombinant protein (Position: L137-E328) .

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

1. Deng, M., Mao, M., Guo, L., Chen, F.-P., Wen, W.-R., Song, Y.-Z. Clinical and molecular study of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency. Exp. Ther. Med. 12: 3294-3300, 2016. 2. Green, R. M., Ananthanarayanan, M., Suchy, F. J., Beier, D. R. Genetic mapping of the Na (+) -taurocholate cotransporting polypeptide to mouse chromosome 12. Mammalian Genome 9: 598-600, 1998. 3. Hagenbuch, B., Meier, P. J. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na (+) /bile acid cotransporter. J. Clin. Invest. 93: 1326-1331, 1994.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Solute carrier family 10 (sodium/bile acid cotransporter family), member 1

Membrane. Multi-pass membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.