Anti-SLC12A6 Antibody Picoband® fluoro488 Vervoeging

Solute carrier family 12 (potassium/chloride transporters), member 6, also called SLC12A6 or KCC3, is a protein that in humans is encoded by the SLC12A6 gene. This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. By radiation hybrid and somatic cell hybrid analyses, this gene is mapped to 15q14. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

Solute carrier family 12 member 6; Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3; SLC12A6; KCC3

SLC12A6

9990

Q9UHW9

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC12A6, different from the related mouse and rat sequences by one amino acid.

Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level) . .

Flow Cytometry

Neurogenesis, Neurology Process, Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels

Immunogen affinity purified.

Liquid

Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.

1. Howard, H. C., Mount, D. B., Rochefort, D., Byun, N., Dupre, N., Lu, J., Fan, X., Song, L., Riviere, J.-B., Prevost, C., Horst, J., Simonati, A., and 12 others. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nature Genet. 32: 384-392, 2002. Note: Erratum: Nature Genet. 32: 681 only, 2002. 2. Salin-Cantegrel, A., Riviere, J.-B., Shekarabi, M., Rasheed, S., DaCal, S., Laganiere, J., Gaudet, R., Rochefort, D., Lesca, G., Gaspar, C., Dion, P. A., Lapointe, J.-Y., Rouleau, G. A.Transit defect of potassium-chloride co-transporter 3 is a major pathogenic mechanism in hereditary motor and sensory neuropathy with agenesis of the corpus callosum. J. Biol. Chem. 286: 28456-28465, 2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

127617 MW

No cross reactivity with other proteins.

6

Solute carrier family 12 member 6

Basolateral cell membrane ; Multi-pass membrane protein .

Solute carrier family 12 member 6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.