Anti-SLC17A5 Antibody Picoband® fluoro647 Vervoeging

Sialin, also known as H (+) /nitrate cotransporter and H (+) /sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene. This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form.

Ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21; USP21; USP23; PP1490

SLC17A5

26503

Q9NRA2

Human, Monkey, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SLC17A5 recombinant protein (Position: M1-R365) .

Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.

Flow Cytometry

Cofactors, Vitamins/Minerals, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Immunogen affinity purified.

Liquid

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.

1. Aula, N., Salomaki, P., Timonen, R., Verheijen, F., Mancini, G., Mansson, J.-E., Aula, P., Peltonen, L. The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation. Am. J. Hum. Genet. 67: 832-840, 2000. 2. Berra, B., Gornati, R., Rapelli, S., Gatti, R., Mancini, G. M. S., Ciana, G., Bembi, B. Infantile sialic acid storage disease: biochemical studies. Am. J. Med. Genet. 58: 24-31, 1995. 3. Biancheri, R., Rossi, A., Verbeek, H. A., Schot, R., Corsolini, F., Assereto, S., Mancini, G. M. S., Verheijen, F. W., Minetti, C., Filocamo, M. Homozygosity for the p.K136E mutation in the SLC17A5 gene as cause of an Italian severe Salla disease. Neurogenetics 6: 195-199, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

104553 MW

6

Ubiquitin specific peptidase 21

Nucleus. Cytoplasm.

AP-2 complex subunit beta

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.